Cat. No. 1241
Chemical Name: cis-4-[Phosphomethyl]-piperidine-2-
Biological ActivityPotent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective. Also available as part of the Mixed NMDA Receptor Tocriset™.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Perez-Pinzon et al (1995) Correlation of CGS 19755 neuroprotection against in vivo excitotoxicity and focal cerebral ischemia. J.Cereb.Blood Flow Metab. 15 865. PMID: 7673380.
Bennett et al (1989) Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors. J.Pharmacol.Exp.Ther. 250 454. PMID: 2547931.
Lehmann et al (1988) CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. J.Pharmacol.Exp.Ther. 246 65. PMID: 2899170.
If you know of a relevant reference for CGS 19755 please let us know.
Citations are publications that use Tocris products. Selected citations for CGS 19755 include:
Richardson and Shelton (2015) N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas. Cereb Cortex 352 156. PMID: 25368340.
Pan et al (2014) Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. J Pharmacol Exp Ther 124 4629. PMID: 25202982.
Pedrazzi et al (2012) Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein. PLoS One 7 e44518. PMID: 22952988.
Jaekel et al (2006) Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. J Clin Invest 147 622. PMID: 16314856.
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Keywords: CGS 19755, supplier, Potent, competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGS19755, Tocris Bioscience, NMDA Receptor Antagonist products