AS 252424

Cat. No. 3671

AS 252424 C14H8FNO4S [900515-16-4]

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Chemical Name: 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

Biological Activity

Potent and selective inhibitor of PI 3-kinase γ (IC50 values are 33 and 935 nM for PI 3-Kγ and PI 3-Kα respectively).

Technical Data

M.Wt:
305.28
Formula:
C14H8FNO4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
900515-16-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Pomel et al (2006) Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J.Med.Chem. 49 3857. PMID: 16789742.

Condliffe et al (2005) Sequential activation of class IB and IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 1432. PMID: 15878979.

If you know of a relevant reference for AS 252424 please let us know.

Citations are publications that use Tocris products. Selected citations for AS 252424 include:

Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol 81 832. PMID: 22434859.

Do you know of a great paper that uses AS 252424 from Tocris? If so please let us know.

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Keywords: AS 252424, supplier, PI3Kgamma, PI3Kγ, PI, 3-kinasegamma, 3-kinaseg, 3-kinaseγ, phosphoinositide, 3, kinases, gamma, γ, signalling, signaling, inositol, lipids, selective, inhibitors, inhibits, AS252424, pi3k, Tocris Bioscience, PI 3-kinase Inhibitor products

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