Insulin (human) recombinant
Biological ActivityEndogenous insulin receptor agonist (Ki = 4.85 nM). Decreases plasma glucose levels, proteolysis, lipolysis and gluconeogenesis and increases glycogen and fatty acid synthesis in vivo.
(Modifications: Disulfide bridge between 6 - 11, 7 -7*, 20 - 19*)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Leney and Tavare (2009) The molecular basis of insulin-stimulated glucose uptake: signalling, trafficking and potential drug targets. J.Endocrinol. 203 1. PMID: 19389739.
Ou et al (2001) The binding characteristics of insulin-MTX to insulin receptor. Hua.Xi.Yi.Ke.Da.Xue.Xue.Bao. 32 538. PMID: 12528542.
Torlinska et al (2000) Age dependent changes of insulin receptors in rat tissues. J.Physiol.Pharmacol. 51 871. PMID: 11220495.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Insulin (human) recombinant
expressed in yeast include:
Stretton et al (2015) GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling. Br J Pharmacol 470 207. PMID: 26348909.
Do you know of a great paper that uses Insulin (human) recombinant
expressed in yeast from Tocris? If so please let us know.
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Keywords: Insulin (human) recombinant, expressed in yeast, supplier, Endogenous, peptide, agonists, IGF, Receptors, nsulin-like, Receptor, Tyrosine, Kinases, RTKs, Tocris Bioscience, Insulin and Insulin-like Receptor Activator products
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