Cat. No. 3434
Biological ActivityPotent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively).
(Modifications: Disulfide bridge between 7 - 16)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gao et al (2004) Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal.Biochem. 328 187. PMID: 15113696.
Bednarek et al (2001) Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. Biochemistry 40 9379. PMID: 11478907.
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Keywords: [Ala17]-MCH, supplier, Potent, MCH, receptors, agonists, Melanin-concentrating, Hormone, MCH1, MCH2, MCH2R, MCHR2, MCH1R, MCHR1, Tocris Bioscience, Melanin-concentrating Hormone Receptor Agonist products
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