GSK 0660

Cat. No. 3433

GSK 0660 C19H18N2O5S2 [1014691-61-2]

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Chemical Name: 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester

Biological Activity

Selective PPARδ antagonist (IC50 values are 0.155, > 10 and 10 μM at PPARδ, PPARα and PPARγ respectively). Exhibits inverse agonist effects when administered by itself.

Technical Data

M.Wt:
418.49
Formula:
C19H18N2O5S2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1014691-61-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Bishop-Bailey and Swales (2008) The role of PPARs in the endothelium: Implications for cancer therapy. PPAR Res. 904851.

Shearer et al (2008) Identification and characterization of a selective peroxisome proliferator-activated receptor β/δ (NR1C2) antagonist. Mol.Endocrinol. 22 523. PMID: 17975020.

Wang (2008) PPAR-δ in vascular pathophysiology. PPAR Res. 164163. PMID: 19132133.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for GSK 0660 include:

Qian et al (2015) Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors. PLoS One 10 e0143439. PMID: 26630504.

Savage et al (2015) RNA-seq identifies a role for the PPARβ/δ inverse agonist GSK0660 in the regulation of TNFα-induced cytokine signaling in retinal endothelial cells. Mol Vis 21 568. PMID: 26015769.

Ramachandran et al (2012) Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. J Biol Chem 287 38028. PMID: 22992727.

Do you know of a great paper that uses GSK 0660 from Tocris? If so please let us know.

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Keywords: GSK 0660, supplier, Selective, PPARδ, PPARdelta, antagonists, Peroxisome, Proliferator-activating, Receptors, GSK0660, Tocris Bioscience, PPARδ Antagonist products

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