S 25585

Cat. No. 3432

S 25585 C22H23F3N4O6S [263849-50-9]

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Chemical Name: 1-Benzoyl-2-[[trans-4-[[[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]amino]methyl]cyclohexyl]carbonyl]hydrazine

Biological Activity

Potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors.

Technical Data

M.Wt:
528.5
Formula:
C22H23F3N4O6S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
263849-50-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kamiji and Inui (2007) Neuropeptide Y receptor selective ligands in the treatment of obesity. 28 664.

Beauverger et al (2005) Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 17 489. PMID: 15601626.

Della-Zuana et al (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor. Int.J.Obes. 28 628.

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Citations are publications that use Tocris products.

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Keywords: S 25585, supplier, Potent, selective, NPY, Y5, antagonists, neuropeptide, Receptors, S25585, neuropeptides, Tocris Bioscience, NPY Receptor Antagonist products

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