Cat. No. 3429
Chemical Name: 4-Iodo-6-phenylpyrimidine
Biological ActivityInhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Winner et al (2008) A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res. 68 7253. PMID: 18794110.
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Citations are publications that use Tocris products. Selected citations for 4-IPP include:
Subbannayya et al (2015) Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. J Biol Chem 15 843. PMID: 26530123.
Salazar et al (2014) The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation. Mol Cancer 13 198. PMID: 25168820.
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Keywords: 4-IPP, supplier, macrophage, migration, inhibitory, factors, MIF, inhibitors, inhibits, suicide, substrates, cytokines, 4IPP, Tocris Bioscience, Cytokine products