Cat. No. 3428

DMT C12H16N2 [61-50-7]

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Alternative Name: Dimethyltryptamine

Chemical Name: N,N-Dimethyl-1H-indole-3-ethanamine

Biological Activity

Endogenous σ1 receptor ligand and psychoactive plant compound (Ki = 14.8 μM). Binding to σ1 inhibits voltage-gated Na+ channels and is responsible for the behavioral effects of DMT. Also a 5-HT2A receptor agonist and inhibitor of 5-HT uptake at plasma membrane serotonin transporters (SERT) (Ki = 4.0 μM).

Technical Data

Soluble to 5 mM in ethanol
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cozzi et al (2009) Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transportere and the vesicle monoamine transporter. J.Neural Transm. 116 1591. PMID: 19756361.

Fontanilla et al (2009) The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 323 934. PMID: 19213917.

If you know of a relevant reference for DMT please let us know.

Citations are publications that use Tocris products. Selected citations for DMT include:

Do-Monte et al (2015) A temporal shift in the circuits mediating retrieval of fear memory. BMC Cancer 519 460. PMID: 25600268.

Do you know of a great paper that uses DMT from Tocris? If so please let us know.

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Keywords: DMT, supplier, sigma, σ, sigma1, σ1, receptors, ligands, 5-HT2A, serotonin, agonists, SERT, transporters, 5-HT, Tocris Bioscience, σ1 Receptor Ligand products

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