Cat. No. 3427
Chemical Name: 1-[(4-Chlorophenyl)methyl]-1H-indol
Biological ActivityProapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Guo et al (2009) Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol.Cancer Ther. 8 441. PMID: 19208825.
Guo et al (2007) Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota. Cancer Res. 68 7403.
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Keywords: Oncrasin 1, supplier, Induces, abnormal, nuclear, aggregation, PKCiota, proapoptotic, Protein, Kinases, C, Apoptosis, Inducers, Oncrasin1, Tocris Bioscience, Protein Kinase C products
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