Cat. No. 3425
Alternative Name: Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala amide
Biological ActivityPotent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
(Modifications: Ala-20 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci.USA 102 874.
Yuan et al (2002) Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity. J.Pharm.Exp.Ther. 301 488.
Bartfai et al (1993) Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc.Natl.Acad.Sci.USA 90 11287.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses M40 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: M40, supplier, Potent, non-selective, galanin, antagonists, GAL, GalR, Receptors, Tocris Bioscience, Galanin Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Non-peptide apelin receptor agonistBML 111
FPR2 (lipoxin A4 receptor) agonistAmylin (rat)
Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptorsCalcitonin (human)
Endogenous calcitonin receptor agonist; inhibits bone resorptionSpexin
Potent GAL2/3 agonist; exhibits anxiolytic effects in vivoMM 54
Potent apelin receptor antagonistMSG 606
Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.