M40

Cat. No. 3425

M40 Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2

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Alternative Name: Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala amide

Biological Activity

Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.

Technical Data

M.Wt:
1981.33
Formula:
C94H145N23O24
Sequence:
GWTLNSAGYLLGPPPALALA

(Modifications: Ala-20 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
143896-17-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci.USA 102 874.

Yuan et al (2002) Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity. J.Pharm.Exp.Ther. 301 488.

Bartfai et al (1993) Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc.Natl.Acad.Sci.USA 90 11287.

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Keywords: M40, supplier, Potent, non-selective, galanin, antagonists, GAL, GalR, Receptors, Tocris Bioscience, Galanin Receptor Antagonist products

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