Cat. No. 3424
Biological ActivityEndogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.
(Modifications: Phe-11 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jansone et al (2004) Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats. Neurosci.Lett. 361 68. PMID: 15135895.
Lindblom et al (1998) Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain. Brain Res. 810 161. PMID: 9813305.
Versteeg et al (1998) Melanocortins and cardiovascular regulation. Eur.J.Pharmacol. 360 1. PMID: 9845266.
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Keywords: gamma1-MSH, supplier, Selective, MC3R, receptor, agonists, Receptors, Melanocortin, γ1-MSH, gamma1-MSH, Tocris Bioscience, Melanocortin (MC) Receptor Agonist products
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