Cat. No. 3424
Biological ActivityEndogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.
(Modifications: Phe-11 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jansone et al (2004) Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats. Neurosci.Lett. 361 68. PMID: 15135895.
Lindblom et al (1998) Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain. Brain Res. 810 161. PMID: 9813305.
Versteeg et al (1998) Melanocortins and cardiovascular regulation. Eur.J.Pharmacol. 360 1. PMID: 9845266.
If you know of a relevant reference for γ1-MSH please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses γ1-MSH from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: gamma1-MSH, supplier, Selective, MC3R, receptor, agonists, Receptors, Melanocortin, γ1-MSH, gamma1-MSH, Tocris Bioscience, Melanocortin (MC) Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Reverse analog of BradykininTASP 0390325
Potent and selective V1B receptor antagonist; orally bioavailableML 233
Non-peptide apelin receptor agonistBML 111
FPR2 (lipoxin A4 receptor) agonistAmylin (rat)
Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptorsCalcitonin (human)
Endogenous calcitonin receptor agonist; inhibits bone resorption
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.