Amylin

Cat. No. 3418

Amylin Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2

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Biological Activity

Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors. Inhibits glucagon secretion, delays gastric emptying and acts as a satiety agent. Displays glucose lowering effects in vivo.

Technical Data

M.Wt:
3903.33
Formula:
C165H261N51O55S2
Sequence:
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY

(Modifications: Tyr-37 = C-terminal amide, Disulfide bridge between 2 - 7)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Store at -20°C
CAS No:
122384-88-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hoogwerf et al (2008) Pramlintide, the synthetic analogue of amylin: physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk. Vasc.Health Risk Manag. 4 355. PMID: 18561511.

Schmitz et al (2004) Amylin agonists: a novel approach in the treatment of diabetes. Diabetes 53 S233. PMID: 15561917.

Castillo et al (1995) Amylin/islet polypeptide: biochemistry, physiology, patho-physiology. Diabete Metab. 21 3. PMID: 7781840.

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Keywords: Amylin, supplier, Endogenous, peptide, agonists, amylin, calcitonin, CGRP, adrenomedullin, receptors, Receptors, Amylin, CT, AMY, Calcitonin, Tocris Bioscience, Calcitonin and Related Receptor Agonist products

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