CP 99994 dihydrochloride
Cat. No. 3417
Chemical Name: (2S,3S)-N-[(2-Methoxyphenyl)methyl]
Biological ActivityHigh affinity NK1 antagonist (Ki = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Lindstrom et al (2007) Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy. J.Pharmacol.Exp.Ther. 322 1286. PMID: 17575073.
Duffy et al (2002) Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther. 301 536. PMID: 11961054.
Shirahase et al (1995) Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2. Br.J.Pharmacol. 115 1215. PMID: 7582548.
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Citations are publications that use Tocris products. Selected citations for CP 99994 dihydrochloride include:
Horn et al (2013) Novel dynamic measures of emetic behavior in musk shrews. Nature 179 60. PMID: 23953843.
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