Cat. No. 0173
Chemical Name: (RS)-3-(2-Carboxypiperazin-4-yl)-pr
Biological ActivityPotent NMDA antagonist. Separate isomer (R)-CPP also available (Cat. No. 0247).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Davies et al (1986) CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]-D-AP5 binding sites on brain membranes and anti-convulsant activity. Brain Res. 382 169. PMID: 2876749.
If you know of a relevant reference for (RS)-CPP please let us know.
Citations are publications that use Tocris products. Selected citations for (RS)-CPP include:
Voyer (2017) Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors Neuropharmacology 112 150. PMID: 27267684.
Ferreira et al (2015) Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala. Front Cell Neurosci 9 161. PMID: 25972785.
Hooks et al (2015) Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex. J Neurosci 35 4418. PMID: 25762684.
Maag et al (2015) Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. Front Neurosci 9 351. PMID: 26483626.
Neuner et al (2015) TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res 281 69. PMID: 25513972.
Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Elife 4. PMID: 25723967.
Zhao et al (2015) Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus. J Neurosci 35 308. PMID: 25568123.
Reinhard et al (2014) Step-by-step instructions for retina recordings with perforated multi electrode arrays. PLoS One 9 e106148. PMID: 25165854.
Toyoizumi et al (2014) Modeling the dynamic interaction of Hebbian and homeostatic plasticity. Neuron 84 497. PMID: 25374364.
Vaghi et al (2014) Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons. Cereb Cortex 24 1247. PMID: 23258346.
Viemari et al (2013) β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Front Neural Circuits 7 179. PMID: 24273495.
Ben-Mabrouk and Tryba (2010) Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity. Eur J Neurosci 31 1219. PMID: 20345918.
Wibrand et al (2010) Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. Eur J Neurosci 31 636. PMID: 20384810.
Ziskin et al (2007) Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci 10 321. PMID: 17293857.
Newman (2005) Calcium increases in retinal glial cells evoked by light-induced neuronal activity. J Neurosci 25 5502. PMID: 15944378.
Smith and Otis (2005) Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit. Proc Natl Acad Sci U S A 102 14901. PMID: 16199519.
Huang et al (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 24 4551. PMID: 15140926.
Abraham et al (2001) Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP. Proc Natl Acad Sci U S A 98 10924. PMID: 11517323.
Sacktor et al (1993) Persistent activation of the ζ isoform of protein kinase C in the maintenance of long-term potentiation. Proc Natl Acad Sci U S A 90 8342. PMID: 8378304.
Tacconi et al (1993) Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis. Br J Pharmacol 108 577. PMID: 8096780.
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Keywords: (RS)-CPP, supplier, Potent, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products
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