(RS)-CPP

Cat. No. 0173

(RS)-CPP C8H17N2O5P [100828-16-8]

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Chemical Name: (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid

Biological Activity

Potent NMDA antagonist. Separate isomer (R)-CPP also available (Cat. No. 0247).

Technical Data

M.Wt:
252.21
Formula:
C8H17N2O5P
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at RT
CAS No:
100828-16-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Davies et al (1986) CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]-D-AP5 binding sites on brain membranes and anti-convulsant activity. Brain Res. 382 169. PMID: 2876749.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (RS)-CPP include:

Maag et al (2015) Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. Front Neurosci 9 351. PMID: 26483626.

Neuner et al (2015) TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res 281 69. PMID: 25513972.

Reinhard et al (2014) Step-by-step instructions for retina recordings with perforated multi electrode arrays. PLoS One 9 e106148. PMID: 25165854.

Toyoizumi et al (2014) Modeling the dynamic interaction of Hebbian and homeostatic plasticity. Neuron 84 497. PMID: 25374364.

Vaghi et al (2014) Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons. Cereb Cortex 24 1247. PMID: 23258346.

Wibrand et al (2010) Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. Eur J Neurosci 31 636. PMID: 20384810.

Smith and Otis (2005) Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit. Proc Natl Acad Sci U S A 102 14901. PMID: 16199519.

Huang et al (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 24 4551. PMID: 15140926.

Tacconi et al (1993) Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis. Br J Pharmacol 108 577. PMID: 8096780.

Do you know of a great paper that uses (RS)-CPP from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: (RS)-CPP, supplier, Potent, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products

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