Cat. No. 3413
Chemical Name: N-Cyclohexyl-6-[[N-(2-methoxyethyl)
Biological ActivityHigh affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. Binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells). Neuroprotective in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Yanamoto et al (2010) Radiosynthesis and evaluation of [11C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1. Nucl.Med.Biol. 37 615. PMID: 20610166.
Ferraguti et al (2008) Metabotropic glutamate 1 receptor: current concepts and perspectives. Pharmacol.Rev. 60 536. PMID: 19112153.
Kohara et al (2008) Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models. Brain Res. 1191 168. PMID: 18164695.
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Keywords: YM 202074, supplier, selective, YM202074, YM, 202074, sesquifumarate, metabotropic, glutamate, receptors, antagonists, mGluR1, mGlu, mGlu1, Group, I, Receptors, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products