Cat. No. 3413
Chemical Name: N-Cyclohexyl-6-[[N-(2-methoxyethyl)
Biological ActivityHigh affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. Binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells). Neuroprotective in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yanamoto et al (2010) Radiosynthesis and evaluation of [11C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1. Nucl.Med.Biol. 37 615. PMID: 20610166.
Ferraguti et al (2008) Metabotropic glutamate 1 receptor: current concepts and perspectives. Pharmacol.Rev. 60 536. PMID: 19112153.
Kohara et al (2008) Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models. Brain Res. 1191 168. PMID: 18164695.
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Keywords: YM 202074, supplier, selective, YM202074, YM, 202074, sesquifumarate, metabotropic, glutamate, receptors, antagonists, mGluR1, mGlu, mGlu1, Group, I, Receptors, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products
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