SR 11237

Cat. No. 3411

SR 11237 C24H28O4 [146670-40-8]

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Alternative Name: BMS 649

Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid

Biological Activity

Pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.

Technical Data

M.Wt:
380.48
Formula:
C24H28O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
146670-40-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Zhou et al (2010) Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages. Mol.Cell.Biochem. 335 283. PMID: 19784811.

Benoit et al (1999) RAR-independent RXR signaling induces t(15;17) leukemia cell maturation. EMBO J. 18 7011. PMID: 10601023.

Chiba et al (1997) Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. Mol.Cell.Biol. 17 3013. PMID: 9154799.

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Keywords: SR 11237, supplier, SR11237, BMS649, retinoid, X, receptors, agonist, pan, RXR, RXRalpha, RTXRbeta, RXRgamma, RXRg, RXRa, RXRb, RXRα, RXRβ, RXRγ, Tocris Bioscience, Retinoid X Receptor Agonist products

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