Cat. No. 3410
Chemical Name: 3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-t
Biological ActivitySelective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Klaholz et al (2000) Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ. Proc.Natl.Acad.Sci. 97 6322.
Abu-Abed et al (1998) Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α. J.Biol.Chem. 273 2409. PMID: 9442090.
Taneja et al (1996) Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 93 6197.
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Keywords: BMS 961, supplier, BMS961, retinoic, acid, receptors, retinoids, rar, rarg, rargamma, rarγ, agonists, selective, Tocris Bioscience, Retinoic Acid Receptor Agonist products
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