BMS 961

Cat. No. 3410

BMS 961 C23H26FNO4 [185629-22-5]

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Chemical Name: 3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid

Biological Activity

Selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.

Technical Data

M.Wt:
399.46
Formula:
C23H26FNO4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
185629-22-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Klaholz et al (2000) Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ. Proc.Natl.Acad.Sci. 97 6322.

Abu-Abed et al (1998) Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α. J.Biol.Chem. 273 2409. PMID: 9442090.

Taneja et al (1996) Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 93 6197.

If you know of a relevant reference for BMS 961 please let us know.

Citations are publications that use Tocris products. Selected citations for BMS 961 include:

Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630. PMID: 27600527.

Centritto et al (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression. PLoS Pathog 7 950. PMID: 25888236.

Do you know of a great paper that uses BMS 961 from Tocris? If so please let us know.

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Keywords: BMS 961, supplier, BMS961, retinoic, acid, receptors, retinoids, rar, rarg, rargamma, rarγ, agonists, selective, Tocris Bioscience, Retinoic Acid Receptor Agonist products

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