R 715

Cat. No. 3407

R 715 Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-DβNal-Ile

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Biological Activity

Potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.

Technical Data

M.Wt:
1140.35
Formula:
C57H81N13O12
Sequence:
KRPPGFSXI

(Modifications: Lys-1 = N-terminal Ac, X = DβNal)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
185052-09-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Abdouh et al (2008) Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors. Br.J.Pharmacol. 154 136. PMID: 18311190.

Quintao et al (2008) Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J.Neurosci. 28 2856. PMID: 18337416.

Gobeil et al (1996) Structure-activity studies of B1 receptor-related peptides. Hypertension. 28 833. PMID: 8901831.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for R 715 include:

Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70. PMID: 24047499.

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Keywords: R 715, supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R715, Tocris Bioscience, Bradykinin Receptor Antagonist products

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