Cat. No. 3407
Biological ActivityPotent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
(Modifications: Lys-1 = N-terminal Ac, X = DβNal)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Abdouh et al (2008) Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors. Br.J.Pharmacol. 154 136. PMID: 18311190.
Quintao et al (2008) Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J.Neurosci. 28 2856. PMID: 18337416.
Gobeil et al (1996) Structure-activity studies of B1 receptor-related peptides. Hypertension. 28 833. PMID: 8901831.
If you know of a relevant reference for R 715 please let us know.
Citations are publications that use Tocris products. Selected citations for R 715 include:
Falsetta et al (2016) A role for bradykinin signaling in chronic vulvar pain. The Journal of Pain. PMID: 27544818.
Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. J Cereb Blood Flow Metab 9 229. PMID: 26124706.
Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70. PMID: 24047499.
Albert-Weissenberger et al (2012) Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation. EMBO Mol Med 32 1747. PMID: 22569191.
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Keywords: R 715, supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R715, Tocris Bioscience, Bradykinin Receptor Antagonist products
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