GLYX 13

Cat. No. 3406

GLYX 13 Thr-Pro-Pro-Thr-NH2

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Biological Activity

NMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Exhibits nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo. Brain penetrant.

Technical Data

M.Wt:
413.47
Formula:
C18H31N5O6
Sequence:
TPPT

(Modifications: Thr-4 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
117928-94-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Burgdorf et al (2009) The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats. Neurobiol.Aging 32 698. PMID: 19446371.

Wood et al (2008) Antinociceptive action of GLYX-13: a N-methyl-D-aspartate receptor glycine site partial agonist. Neuroreport. 19 1059. PMID: 18580579.

Zhang et al (2008) A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus. 55 1238. PMID: 18796308.

Moskal et al (2005) GLYX-13: A monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator. Neuropharmacology 49 1077. PMID: 16051282.

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Keywords: GLYX 13, supplier, NMDA, receptor, partial, agonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, GLYX13, Tocris Bioscience, NMDA Receptor Agonist products

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