S 32826

Cat. No. 3404

S 32826 C21H34NO4PNa2 [1103672-43-0]

Price and Availability

For S 32826 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: [4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt

Biological Activity

Inhibitor of autotaxin (IC50 = 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μM. Inhibits LPA release from adipocytes (IC50 = 90 nM).

Technical Data

M.Wt:
441.45
Formula:
C21H34NO4PNa2
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1103672-43-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Li et al (2011) Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. Mol.Cancer 10 18. PMID: 21314984.

Gaetano et al (2009) Inhibition of autotaxin production or activity blocks lysophosphatiylcholine-induced migration of human breast cancer and melanoma cells. Mol.Carcinogenesis 48 801.

Ferry et al (2008) S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. J.Pharmacol.Exp.Ther. 327 809. PMID: 18755937.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses S 32826 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: S 32826, supplier, S32826, autotaxin, atx, inhibits, inhibitors, LPA, lysophosphatidic, acid, lipids, enpp2, lysophospholipases, phospholipases, Tocris Bioscience, Autotaxin Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

New Products in this Area

XEN 445

Selective endothelial lipase inhibitor; orally bioavailable

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.