RuBi-GABA

Cat. No. 3400

RuBi-GABA C42H39F6N5O2P2Ru [1028141-88-9]

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Chemical Name: (bis(2,2'-Bipyridine-N,N')triphenylphosphine)-4-aminobutyric acid ruthenium hexafluorophosphate complex

Biological Activity

Ruthenium-bipyridine-triphenylphosphine caged GABA (Cat. No. 0344) that is excited by visible wavelengths. Provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Produces GABA receptor-mediated currents in pyramidal neurons in vitro and displays no effect on endogenous GABAergic or glutamatergic transmission at concentrations effective for uncaging.

Licensing Information

Sold under licence from Columbia University

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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Rial Verde et al (2008) Photorelease of GABA with visible light using an inorganic caging group. Front.Neural Circuits 2 2. PMID: 18946542.

Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882. PMID: 12537482.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for RuBi-GABA include:

Amatrudo et al (2015) Caged compounds for multichromic optical interrogation of neural systems. Int J Oncol 41 42491. PMID: 25471355.

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Keywords: RuBi-GABA, supplier, Caged, GABA, GABAA, GABAC, Receptors, GABAB, Tocris Bioscience, GABAB Receptor Agonist products

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