Cat. No. 1064
Chemical Name: [8β(S)]-9,10-Didehydro-N-[1-(hydroxy
Biological ActivityMixed 5-HT1/5-HT2 receptor antagonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. PMID: 7938165.
Merck Index 12 6217.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Methysergide maleate include:
Williams et al (2012) Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine. Neuropsychopharmacology 37 2285. PMID: 22692564.
Moreno et al (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. Hypertension 31 1863. PMID: 21289196.
Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694. PMID: 20512126.
Dacks et al (2009) Serotonin modulates olfactory processing in the antennal lobe of Drosophila. J Neurosci 23 366. PMID: 19863268.
Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. Neuron 29 13909. PMID: 19890001.
González-Maeso et al (2007) Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. J Neurosci 53 439. PMID: 17270739.
View Related Products by Target
View Related Products by Product Action
Keywords: Methysergide maleate, supplier, 5-HT1, 5-HT2, antagonists, Non-Selective, 5-Hydroxytryptamine, Receptors, Serotonin, Tocris Bioscience, Non-selective 5-HT Antagonist products