Myelin Basic Protein (87-99)

Cat. No. 3399

Myelin Basic Protein (87-99) Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro

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Biological Activity

Encephalitogenic peptide that induces T cell proliferation with Th1 polarization in the CNS. Major antigenic component implicated in the pathophysiology of multiple sclerosis.

Technical Data

M.Wt:
1555.8
Formula:
C74H114N20O17
Sequence:
VHFFKNIVTPRTP
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
118506-26-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Deraos et al (2008) Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP87-99) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: Implications in triggering disease. J.Med.Chem. 51 7834. PMID: 19053745.

Hofstetter et al (2005) Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis? J.Immunol. 22 4598.

Jones et al (1992) The synthetic 87-99 peptide of myelin basic protein is encelphalitogenic in Buffalo rats. J.Neuroimmunol. 37 203. PMID: 1373154.

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Keywords: Myelin Basic Protein (87-99), supplier, antigenic, component, implicated, pathophysiology, multiple, sclerosis, Encephalitogenic, peptide, Neuronal, Metabolism, Tocris Bioscience, Neuronal Metabolism products

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