LY 2365109 hydrochloride

Cat. No. 3397

LY 2365109 hydrochloride C22H27NO5.HCl [868265-28-5]

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Chemical Name: N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride

Biological Activity

Potent and selective glycine transporter 1 (GlyT1) inhibitor (IC50 values are 15.8 and > 30 000 nM at GlyT1 and GlyT2 respectively). Induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Produces profound locomotor and respiratory impairments at higher doses.

Technical Data

M.Wt:
421.91
Formula:
C22H27NO5.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
868265-28-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Perry et al (2008) Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs cortical brain areas. Neuropharmacology 55 743. PMID: 18602930.

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Keywords: LY 2365109 hydrochloride, supplier, Potent, selective, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, LY2365109, hydrochloride, Tocris Bioscience, Glycine Transporter Inhibitor products

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