Cat. No. 3396
Biological ActivitySynthetic vasopressin analog that acts as an agonist at V1B and V2 receptors (EC50 values are 11.4 and 23.9 nM and Ki values are 5.84 and 65.9 nM respectively). Prevents polycystic kidney disease formation and exhibits antidiuretic, antiproliferative, hemostatic and hypotensive activity in vivo.
(Modifications: X = Mpr, Arg-8 = D-Arg, Gly-9 = C-terminal amide, Cyclized = X-1 - Cys-6)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Torres (2008) Vasopressin antagonists in polycystic kidney disease. Semin.Nephrol. 28 306. PMID: 18519091.
Gomez et al (2006) Desmopressin and other synthetic vasopressin analogues in cancer treatment. Bull.Cancer 93 E7. PMID: 16517412.
Saito et al (1997) 1-Desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V1b vasopressin receptor. Biochem.Pharmacol. 53 1711. PMID: 9264324.
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Keywords: Desmopressin, supplier, Synthetic, vasopressin, analog, V1B, V2, agonists, Receptors, Vasopressin, Tocris Bioscience, Vasopressin Receptor Agonist products
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