Amyloid β-peptide (42-1) (human)

Cat. No. 3391

Amyloid b-peptide (42-1) (human) Ala-Ile-Val-Val-Gly-Gly-Val-Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly-Val-Asp-Glu-Ala-Phe-Phe-Val-Leu-Lys-Gln-His-His-Val-Glu-Tyr-Gly-Ser-Asp-His-Arg-Phe-Glu-Ala-Asp

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Biological Activity

Inactive control peptide for amyloid β-peptide (1-42) (Cat. No. 1428), the predominant form of amyloid β-peptide found in the brains of patients with Alzheimer's disease.

Technical Data

M.Wt:
4514.08
Formula:
C203H311N55O60S
Sequence:
AIVVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD
Solubility:
Soluble to 0.50 mg/ml in water
Storage:
Store at -20°C
CAS No:
317366-82-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Xiong et al (2007) Mitochondrial respiratory inhibition and oxidative stress elevate β-secretase (BACE1) proteins and activity in vivo in the rat retina. Exp.Brain Res. 181 435. PMID: 17429617.

Boyd-Kimball et al (2005) Proteomic identification of proteins oxidized by Aβ(1-42) in synaptosomes: Implications for Alzheimer's disease. Brain Res. 1004 206. PMID: 15885219.

Walsh et al (2002) Amyloid-beta peotide is toxic to neurons in vivo via indirect mechanisms. Neurobiol.Dis. 10 20. PMID: 12079400.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Amyloid β-peptide (42-1) (human) include:

Esposito et al (2011) Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement. PLoS One 6 e28668. PMID: 22163051.

Do you know of a great paper that uses Amyloid β-peptide (42-1) (human) from Tocris? If so please let us know.

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