Clonidine hydrochloride

Cat. No. 0690

Clonidine hydrochloride C9H9Cl2N3.HCl [4205-91-8]

Price and Availability

For Clonidine hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride

Biological Activity

Prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Technical Data

M.Wt:
266.56
Formula:
C9H9Cl2N3.HCl
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
4205-91-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Williams et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 4 295. PMID: 18391949.

Armitsu et al (1998) Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 286 681. PMID: 9694921.

Silva et al (1996) Dual effect of clonidine on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 277 872. PMID: 8627569.

Greney et al (1994) Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 265 R1. PMID: 7883019.

Ernsberger et al (1987) Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 134 1. PMID: 3030779.

Merck Index 12 2450.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Clonidine hydrochloride include:

Cinelli et al (2013) Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit. Physiol Rep 1 e00122. PMID: 24400133.

Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110. PMID: 21315691.

Liu et al (2011) Ongoing pain in the MIA model of osteoarthritis. Neurosci Lett 493 72. PMID: 21241772.

Garzón et al (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. Mol Pain 5 11. PMID: 19284549.

Do you know of a great paper that uses Clonidine hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: Clonidine hydrochloride, supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenergic, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, agonists, I1, ligand, Receptors, Imidazoline, Tocris Bioscience, Adrenergic α2 Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Parkinson's disease: Neurobiology and Therapeutic Strategies

Written by Anthony H.V. Schapira

Parkinson's Life Science Poster

Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD. Request copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

New Products in this Area

AdTx1

Selective, high affinity, non-competitive α1A adrenoceptor antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

IVBM 2016

IVBM 2016

October 30 - November 3, 2016

Boston, MA, USA

Booth: 2