Cat. No. 0690
Chemical Name: 2-[(2,6-Dichlorophenyl)amino-2-imid
Biological ActivityPrototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Williams et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 4 295. PMID: 18391949.
Armitsu et al (1998) Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 286 681. PMID: 9694921.
Silva et al (1996) Dual effect of clonidine on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 277 872. PMID: 8627569.
Greney et al (1994) Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 265 R1. PMID: 7883019.
Ernsberger et al (1987) Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 134 1. PMID: 3030779.
Merck Index 12 2450.
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Citations are publications that use Tocris products. Selected citations for Clonidine hydrochloride include:
Devoto et al (2015) Selective inhibition of dopamine-β-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex. Mol Pain 5 e00393. PMID: 26516613.
Cinelli et al (2013) Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit. Physiol Rep 1 e00122. PMID: 24400133.
Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110. PMID: 21315691.
Liu et al (2011) Ongoing pain in the MIA model of osteoarthritis. Neurosci Lett 493 72. PMID: 21241772.
Okun et al (2011) Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Purinergic Signal 7 4. PMID: 21219650.
Garzón et al (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. Mol Pain 5 11. PMID: 19284549.
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Keywords: Clonidine hydrochloride, supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenergic, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, agonists, I1, ligand, Receptors, Imidazoline, Tocris Bioscience, Adrenergic α2 Receptor Agonist products