Cat. No. 3389

Bicalutamide C18H14F4N2O4S [90357-06-5]

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Special Conditions

No more than 1 g per individual per year to be sold without prior permission from the license holder.

Alternative Names: Casodex, ICI 176,334

Chemical Name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide

Biological Activity

Orally active non-steroidal androgen receptor antagonist (IC50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo.

Licensing Information

Sold for research purposes only under agreement from AstraZeneca

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Furr and Tucker (1996) The preclinical development of bicalutamide: pharmacodynamics and mechanism of action. Urology 47 13. PMID: 8560673.

Tucker et al (1988) Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides. J.Med.Chem. 31 954. PMID: 3361581.

Furr et al (1987) ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen. J.Endocrinol. 113 R7. PMID: 3625091.

If you know of a relevant reference for Bicalutamide please let us know.

Citations are publications that use Tocris products. Selected citations for Bicalutamide include:

Gambara et al (2015) TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo. J Cell Mol Med 19 327. PMID: 25444175.

Ivachtchenko et al (2014) Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment. PLoS One 5 133. PMID: 24494031.

Ishizaki et al (2013) Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer. Sci Rep 3 1528. PMID: 23524847.

Do you know of a great paper that uses Bicalutamide from Tocris? If so please let us know.

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Keywords: Bicalutamide, supplier, Non-steroidal, Androgen, receptor, antagonists, Dihydrotestosterone, Receptors, AstraZeneca, ICI176,334, chemotherapeutics, Tocris Bioscience, Androgen Receptor Antagonist products

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