Anastrozole

Cat. No. 3388

Anastrozole C17H19N5 [120511-73-1]

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Special Conditions

No more than 1 g per individual per year to be sold without prior permission from the license holder.

Alternative Name: ZD1033

Chemical Name: α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile

Biological Activity

Potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.

Licensing Information

Sold for research purposes only under agreement from AstraZeneca

Technical Data

M.Wt:
293.37
Formula:
C17H19N5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
120511-73-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Buzda (2001) Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting? Br.J.Cancer 85 6. PMID: 11900212.

Goss and Tye (1997) Anastrozole: a new selective nonsteroidal aromatase inhibitor. Oncology 11 1697. PMID: 9394367.

Dukes et al (1996) The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 58 439. PMID: 8903429.

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Keywords: Anastrozole, supplier, Potent, aromatase, CYP19, inhibitors, inhibits, ERR, Estrogen, Receptors, Cytochrome, P450, AstraZeneca, ZD, 1033, Tocris Bioscience, Cytochrome P450 Inhibitor products

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