GW 791343 hydrochloride
Cat. No. 3385
Chemical Name: 2-[(3,4-Difluorophenyl)amino]-N-[2-
Biological ActivityP2X7 allosteric modulator. Exhibits species-specific activity; acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Michel et al (2008) Negative and positive allosteric modulators of the P2X7 receptor. Br.J.Pharmacol. 153 737. PMID: 18071294.
Michel et al (2008) Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects. Br.J.Pharmacol. 155 738. PMID: 18660826.
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