GW 791343 hydrochloride

Cat. No. 3385

GW 791343 hydrochloride C20H24F2N4O.3HCl [309712-55-8]

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Chemical Name: 2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride

Biological Activity

P2X7 allosteric modulator. Exhibits species-specific activity; acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7.

Technical Data

M.Wt:
483.81
Formula:
C20H24F2N4O.3HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
309712-55-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Michel et al (2008) Negative and positive allosteric modulators of the P2X7 receptor. Br.J.Pharmacol. 153 737. PMID: 18071294.

Michel et al (2008) Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects. Br.J.Pharmacol. 155 738. PMID: 18660826.

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Keywords: GW 791343 hydrochloride, supplier, P2X7, allosteric, modulators, Receptors, Purinergic, purinoceptors, GW791343, hydrochloride, Tocris Bioscience, Purinergic (P2X) Receptor Modulator products

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