Cat. No. 3384
Chemical Name: O-(2-Acetamido-2-deoxy-D-glucopyran
Biological ActivityO-GlcNAc-β-N-acetylglucosaminidase (O-GlcNAcase) and β-hexosaminidase inhibitor (Ki values are 46 and 36 nM respectively) that increases O-GlcNAc levels ~ 2-fold in HT29 cells. Z-linked isomer is more potent than the E isomer.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Perreira et al (2006) Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg.Med.Chem. 14 837. PMID: 16214344.
Macauley et al (2005) O-GlcNAcase uses substrate-assisted catalysis. J.Biol.Chem. 280 25313. PMID: 15795231.
Dong and Hart (1994) Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol. J.Biol.Chem. 269 19321. PMID: 8034696.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses (Z)-Pugnac from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Pugnac, supplier, O-GlcNAcase, β-hexosaminidase, beta-hexosaminidase, O-GlcNAc-β-N-acetylglucosaminidase, O-GlcNAc-beta-N-acetylglucosaminidase, inhibitors, inhibits, Hydrolases, Tocris Bioscience, Other Hydrolase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrantJZP 430
Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitorBPTES
Selective allosteric glutaminase (GLS1) inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.