(Z)-Pugnac

Cat. No. 3384

Pugnac C15H19N3O7 [132489-69-1]

Price and Availability

For (Z)-Pugnac pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate

Biological Activity

O-GlcNAc-β-N-acetylglucosaminidase (O-GlcNAcase) and β-hexosaminidase inhibitor (Ki values are 46 and 36 nM respectively) that increases O-GlcNAc levels ~ 2-fold in HT29 cells. Z-linked isomer is more potent than the E isomer.

Technical Data

M.Wt:
353.33
Formula:
C15H19N3O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
132489-69-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Perreira et al (2006) Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg.Med.Chem. 14 837. PMID: 16214344.

Macauley et al (2005) O-GlcNAcase uses substrate-assisted catalysis. J.Biol.Chem. 280 25313. PMID: 15795231.

Dong and Hart (1994) Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol. J.Biol.Chem. 269 19321. PMID: 8034696.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses (Z)-Pugnac from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Pugnac, supplier, O-GlcNAcase, β-hexosaminidase, beta-hexosaminidase, O-GlcNAc-β-N-acetylglucosaminidase, O-GlcNAc-beta-N-acetylglucosaminidase, inhibitors, inhibits, Hydrolases, Tocris Bioscience, Other Hydrolase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2015)

Our New Product guide highlights over 150 new products added in the second half of 2015. View PDF today.

divider line

New Products in this Area

TPPU

Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrant

JZP 430

Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor

BPTES

Selective allosteric glutaminase (GLS1) inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.