Cat. No. 3383
Alternative Name: ML 108
Chemical Name: 3-Amino-N-(4-methoxybenzyl)-4,6-dim
Biological ActivitySelective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM). Induces 21-fold shift in ACh potency at M4 receptor. Displays no activity at other mAChR subtypes.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Brady et al (2008) Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J.Pharmacol.Exp.Ther. 327 941. PMID: 18772318.
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Keywords: VU 152100, supplier, muscarinic, receptors, mAChR, M4, acetylcholine, ACh, selective, positive, allosteric, modulators, VU152100, M4, PAM, ML, 108, ML_108, ML108, Tocris Bioscience, M4 Receptor Modulator products
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