Cat. No. 3381
Chemical Name: N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosat
Biological ActivityMetabolically stable anandamide uptake inhibitor (IC50 = 2.1 - 2.5 μM) and fatty acid amide hydrolase (FAAH) inhibitor (Ki = 3.18 μM). Inhibits N-arachidonylethanolamine (AEA) accumulation (IC50 = 24 μM) and hydrolysis (Ki = 3 μM), and inhibits N-palmitoylethanolamine (PEA) hydrolysis (IC50 = 36 μM) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC50 values are 189 and 271 nM at CB2 and CB1 receptors respectively).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Hillard et al (2007) Studies of anandamide accumulation inhibitors in cerebellar granule neurons. J.Mol.Neurosci. 33 18. PMID: 17901541.
Kaczocha et al (2006) Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J.Biol.Chem. 281 9066. PMID: 16461355.
Fegley et al (2004) Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc.Natl.Acad.Sci.USA 101 8756.
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Keywords: AM 1172, supplier, Anandamide, uptake, inhibitors, inhibits, AMT, FAAH, inhibitor, CB, receptors, partial, agonists, cannabinoid, fatty, acid, amide, hydrolase, neurotransmitter, transporters, AM1172, cb2r, cb1r, Tocris Bioscience, Cannabinoid Transporter Inhibitor products
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