AM 1172

Cat. No. 3381

AM 1172 C27H39NO2 [251908-92-6]

Price and Availability

For AM 1172 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxybenzamide

Biological Activity

Metabolically stable anandamide uptake inhibitor (IC50 = 2.1 - 2.5 μM) and fatty acid amide hydrolase (FAAH) inhibitor (Ki = 3.18 μM). Inhibits N-arachidonylethanolamine (AEA) accumulation (IC50 = 24 μM) and hydrolysis (Ki = 3 μM), and inhibits N-palmitoylethanolamine (PEA) hydrolysis (IC50 = 36 μM) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC50 values are 189 and 271 nM at CB2 and CB1 receptors respectively).

Technical Data

M.Wt:
409.6
Formula:
C27H39NO2
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml)
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
251908-92-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Hillard et al (2007) Studies of anandamide accumulation inhibitors in cerebellar granule neurons. J.Mol.Neurosci. 33 18. PMID: 17901541.

Kaczocha et al (2006) Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J.Biol.Chem. 281 9066. PMID: 16461355.

Fegley et al (2004) Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc.Natl.Acad.Sci.USA 101 8756.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses AM 1172 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: AM 1172, supplier, Anandamide, uptake, inhibitors, inhibits, AMT, FAAH, inhibitor, CB, receptors, partial, agonists, cannabinoid, fatty, acid, amide, hydrolase, neurotransmitter, transporters, AM1172, cb2r, cb1r, Tocris Bioscience, Cannabinoid Transporter Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Cannabinoid Review

Written by Roger Pertwee

Cannabinoid Receptor Ligands Scientific Review

Our Cannabinoid review gives an overview of the pharmacological ligands used to study the cannabinoid CB1 and CB2 receptors. Request copy or view PDF today.

divider line

New Products in this Area

ML 352 hydrochloride

High affinity and selective presynaptic choline transporter (CHT) inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.