Ac-RYYRIK-NH2

Cat. No. 1239

Ac-RYYRIK-NH2 Ac-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2

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Biological Activity

High affinity ligand for the NOP site (Ki = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.

Technical Data

M.Wt:
939.12
Formula:
C44H70N14O9
Sequence:
RYYRIK

(Modifications: Arg-1 = N-terminal Ac, Lys-6 = C-terminal amide)

Storage:
Desiccate at -20°C
CAS No:
200959-48-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet

Berger et al (1999) Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br.J.Pharmacol. 126 555. PMID: 10188961.

Berger et al (1999) Acetyl-RYYRIK-NH2, a nociceptin/orphanin FQ (noc/OFQ) receptor ligand, exhibits properties of an antagonist and agonist as well. Regul.Pept. 80 122. PMID: 10998548.

Dooley et al (1997) Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J.Pharmacol.Exp.Ther. 283 735. PMID: 9353393.

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Keywords: Ac-RYYRIK-NH2, supplier, High, affinity, NOP, ligands, Nociceptin, Receptors, ORL1, OP4, Opioid, Tocris Bioscience, NOP Receptor Ligand products

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