Cat. No. 3379
Chemical Name: 3,5-Diamino-6-chloro-N-[imino(pheny
Biological ActivityTRPP3 channel inhibitor (IC50 = 0.14 μM). Also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Derivative of amiloride (Cat. No. 0890).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. Mol.Pharmacol. 72 1576. PMID: 17804601.
Barbry et al (1989) Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels. Biochemistry. 28 3744. PMID: 2546581.
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Keywords: Phenamil, supplier, TRPP3, TRP, antagonists, sodium, channels, blocker, amiloride, Na, epithelial, Tocris Bioscience, TRPP Blocker products
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