Phenamil

Cat. No. 3379

Phenamil C12H12ClN7O.CH3SO3H [1161-94-0]

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Chemical Name: 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt

Biological Activity

TRPP3 channel inhibitor (IC50 = 0.14 μM). Also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Derivative of amiloride (Cat. No. 0890).

Technical Data

M.Wt:
401.83
Formula:
C12H12ClN7O.CH3SO3H
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1161-94-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. Mol.Pharmacol. 72 1576. PMID: 17804601.

Barbry et al (1989) Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels. Biochemistry. 28 3744. PMID: 2546581.

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Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: Phenamil, supplier, TRPP3, TRP, antagonists, sodium, channels, blocker, amiloride, Na, epithelial, Tocris Bioscience, TRPP Blocker products

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