EIPA

Cat. No. 3378

EIPA C11H18ClN7O [1154-25-2]

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Alternative Name: Ethylisopropyl amiloride

Chemical Name: 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide

Biological Activity

TRPP3 channel inhibitor (IC50 = 10.5 μM). Inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride (Cat. No. 0890).

Technical Data

M.Wt:
299.76
Formula:
C11H18ClN7O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1154-25-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Horinouchi et al (2008) Functional role of Na+/H+ exchanger in Ca2+ influx mediated via human endothelin type A receptor stably expressed in Chinese hamster ovary cells. J.Pharm.Sci. 107 456. PMID: 18678984.

Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. Mol.Pharmacol. 72 1576. PMID: 17804601.

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View Related Products by Product Action

Keywords: EIPA, supplier, sodium, hydrogen, exchangers, NHE-1, NHE, blockers, inhibitors, inhibits, TRPP3, antagonists, Amiloride, ethylisopropyl, amiloride, Tocris Bioscience, TRPP Blocker products

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