Dolastatin 10 trifluoroacetate

Cat. No. 3375

Dolastatin 10 trifluoroacetate C42H68N6O6S.CF3CO2H

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Chemical Name: N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamide trifluoroacetate

Biological Activity

Tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (Ki = 1.4 μM) and induces tubulin aggregation in vitro.

Technical Data

M.Wt:
899.11
Formula:
C42H68N6O6S.CF3CO2H
Solubility:
Soluble in DMSO
Purity:
>95 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bai et al (1995) Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol.Pharmacol. 47 965. PMID: 7746283.

Bai et al (1990) Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J.Biol.Chem. 265 17141. PMID: 2211617.

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Keywords: Dolastatin 10 trifluoroacetate, supplier, tubulin, polymerization, inhibitors, inhibits, aggregation, inducers, induces, microtubule, 110417-88-4, Tocris Bioscience, Microtubule products

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