Valinomycin

Cat. No. 3373

Valinomycin C54H90N6O18 [2001-95-8]

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Chemical Name: Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)

Biological Activity

Selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

Technical Data

M.Wt:
1111.32
Formula:
C54H90N6O18
Solubility:
Soluble to 25 mM in DMSO and to 25 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
2001-95-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Rose and Jenkins (2007) The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes. Bioelectrochem. 70 387.

Abdalah et al (2006) Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci.Letts. 405 68.

Davidson and Berman (1985) Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum. J.Biol.Chem. 260 7325. PMID: 3158656.

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Citations are publications that use Tocris products. Selected citations for Valinomycin include:

Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. J Cancer 11 e0154932. PMID: 27183222.

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Keywords: Valinomycin, supplier, Selective, K+, ionophores, Potassium, antibiotics, Tocris Bioscience, Ionophore products

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