TCS OX2 29
Cat. No. 3371
Chemical Name: (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2
Biological ActivityPotent and selective OX2 receptor antagonist (IC50 = 40 nM). Displays >250-fold selectivity for OX2 over OX1 and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Mould et al (2014) Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br.J.Pharmacol. 171 351. PMID: 23692283.
Hirose et al (2003) N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist. Bioorg.Med.Chem.Lett. 13 4497. PMID: 14643355.
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Keywords: TCS OX2 29, supplier, Potent, selective, OX2, antagonists, Orexin2, Receptors, TCSOX229, Tocris Bioscience, OX2 Receptor Antagonist products
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October 30 - November 3, 2016
Boston, MA, USA