Cat. No. 3370
Chemical Name: (±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrol
Biological ActivityPotent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca2+ mobilization and cellular proliferation in vitro (pEC50 values are 6.9, 7.0 and 7.5 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Gardell et al (2008) Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 327 799. PMID: 18768780.
Seitzberg et al (2008) Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 51 5490. PMID: 18720984.
If you know of a relevant reference for AC 264613 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses AC 264613 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: AC 264613, supplier, Potent, selective, PAR2, agonists, receptors, protease-activated, proteinase-activated, AC264613, Tocris Bioscience, Protease-Activated Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Negative control for ELA-14 (Cat.No.6293).ELA-14 (human)
Potent apelin (APJ) receptor agonistRetrobradykinin
Reverse analog of BradykininTASP 0390325
Potent and selective V1B receptor antagonist; orally bioavailableML 233
Non-peptide apelin receptor agonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.