Cat. No. 1236

BHQ C14H22O2 [88-58-4]

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Chemical Name: 1,4-Dihydroxy-2,5-di-tert-butylbenzene

Biological Activity

A selective inhibitor of endoplasmic reticulum Ca2+-ATPase.

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Dettbarn and Palade (1999) Effects of three sarcoplasmic/endoplasmic Ca++ pump inhibitors on release channels and intracellular stores. J.Pharmacol.Exp.Ther. 285 739. PMID: 9580621.

Fusi et al (1999) 2,5-Di-t-butyl-1,4 benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta. Eur.J.Pharmacol. 366 181. PMID: 10082199.

Jan et al (1999) Mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced Ca2+ signals in Madin Darby canine kidney cells. Eur.J.Pharmacol. 365 111. PMID: 9988129.

Hassessian et al (1994) Blockade of the inward rectifier potassium current by the Ca2+-ATPase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ). Br.J.Pharmacol. 112 1118. PMID: 7952872.

If you know of a relevant reference for BHQ please let us know.

Citations are publications that use Tocris products. Selected citations for BHQ include:

Inagaki et al (2014) Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca2+ channel due to a familial hemiplegic migraine mutation. Neuron 81 91. PMID: 24411734.

Dai et al (2012) Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells. J Biol Chem 287 14586. PMID: 22418436.

Zhdanov et al (2011) Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria. Cell Mol Life Sci 68 903. PMID: 20820851.

Do you know of a great paper that uses BHQ from Tocris? If so please let us know.

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Keywords: BHQ, supplier, inhibitors, inhibits, SERCA, ATPase, Ca2+, modulators, Ca2+-ATPase, Signaling, Signalling, Calcium, P-Type, ATPases, Calcium-ATPase, Ion, Transporters, Pumps, Tocris Bioscience, Ca2+-ATPase Inhibitor products

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