WAY 200070

Cat. No. 3366

WAY 200070 C13H8BrNO3 [440122-66-7]

Price and Availability

For WAY 200070 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

Biological Activity

Selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Displays antianxiolytic and antidepressive effects in vivo.

Technical Data

M.Wt:
306.11
Formula:
C13H8BrNO3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
440122-66-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Clipperton et al (2008) Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology 33 2362. PMID: 18004284.

Hughes et al (2008) WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology 54 1136. PMID: 18423777.

Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021. PMID: 15456246.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for WAY 200070 include:

Sellers et al (2015) Rapid modulation of synaptogenesis and spinogenesis by 17β-estradiol in primary cortical neurons. Front Cell Neurosci 9 137. PMID: 25926772.

Cao et al (2012) Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain 13 685. PMID: 22698981.

Do you know of a great paper that uses WAY 200070 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: WAY 200070, supplier, Selective, ERβ, ERbeta, agonists, estrogen, receptors, WAY200070, Tocris Bioscience, Estrogen and Related Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

Estrogen Pathway

Estrogen Signaling Pathway

Estrogen controls many cellular processes including growth, differentiation and function of the reproductive system. View pathway or download PDF today.

divider line

New Products in this Area

EC 19

Synthetic retinoid; induces differentiation of stem cells

SI-2 hydrochloride

Steroid receptor coactivator 3 (SRC-3) inhibitor

SR 0987

T cell-specific RORγ (RORγt) agonist

WAY 252623

Potent LXR agonist

SR 9009

Rev-Erbα/β agonist

SR 9238

Potent and selective LXR inverse agonist

IP7e

Potent Nurr1 activator

Sign-up for new product e-alerts
divider line

Bio-Techne Events

IVBM 2016

IVBM 2016

October 30 - November 3, 2016

Boston, MA, USA

Booth: 2