Tenovin-1

Cat. No. 3365

Tenovin-1 C20H23N3O2S [380315-80-0]

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Chemical Name: N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide

Biological Activity

p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro.

Technical Data

M.Wt:
369.48
Formula:
C20H23N3O2S
Solubility:
Soluble to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
380315-80-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Lain et al (2008) Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 454. PMID: 18455128.

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Keywords: Tenovin-1, supplier, activators, p53, transcriptional, activity, Protects, against, MDM2-mediated, degradation, Transcription, Factors, Ligases, Tocris Bioscience, Ubiquitin E3 Ligase products

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