Cat. No. 3362
Chemical Name: 1-[(1-Oxopropoxy)methyl]-1H-pyrrole
Biological ActivityRestores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kumar et al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168. PMID: 17485365.
Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921. PMID: 16557267.
Bykov et al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384. PMID: 15998635.
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Keywords: MIRA-1, supplier, Restores, mutant, p53, activity, proapoptotic, Transcription, Factors, Tocris Bioscience, p53 products
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