Cat. No. 1225
Chemical Name: 1,4-Bis(3,5-Dichloro-2-pyridinyloxy
Biological ActivityAgonist of the constitutive androstane receptor (CAR) (EC50 = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Tzameli et al (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 20 2951. PMID: 10757780.
Ledda-Columbano et al (1998) In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway. Oncogene 17 1039. PMID: 9747883.
Poland et al (1980) 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity. Mol.Pharmacol. 18 571. PMID: 7464820.
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Keywords: TCPOBOP, supplier, agonists, nuclear, receptor, CAR, constitutive, androstane, receptors, mitogens, mitogenic, Tocris Bioscience, Constitutive Androstane Receptor Agonist products
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