Ellipticine

Cat. No. 3357

Ellipticine C17H14N2 [519-23-3]

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Chemical Name: 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole

Biological Activity

Naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.

Technical Data

M.Wt:
246.31
Formula:
C17H14N2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
519-23-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ohashi et al (1995) Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn.J.Cancer Res. 86 819. PMID: 7591958.

Tewey et al (1984) Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J.Biol.Chem. 259 9182. PMID: 6086625.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ellipticine include:

Kishikawa et al (2015) Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget 6 8339. PMID: 25826076.

Do you know of a great paper that uses Ellipticine from Tocris? If so please let us know.

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Keywords: Ellipticine, supplier, apoptosis, inducers, DNA, topoisomerase, II, inhibits, inhibitors, p53, phosphorylation, antitumor, intercalating, agents, plant, alkaloid, protein, kinase, CK2, Tocris Bioscience, DNA Topoisomerase Inhibitor products

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