Cat. No. 3357
Chemical Name: 5,11-Dimethyl-6H-pyrido[4,3-b]carba
Biological ActivityNaturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ohashi et al (1995) Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn.J.Cancer Res. 86 819. PMID: 7591958.
Tewey et al (1984) Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J.Biol.Chem. 259 9182. PMID: 6086625.
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Citations are publications that use Tocris products. Selected citations for Ellipticine include:
Kishikawa et al (2015) Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget 6 8339. PMID: 25826076.
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Keywords: Ellipticine, supplier, apoptosis, inducers, DNA, topoisomerase, II, inhibits, inhibitors, p53, phosphorylation, antitumor, intercalating, agents, plant, alkaloid, protein, kinase, CK2, Tocris Bioscience, DNA Topoisomerase Inhibitor products