PNU 177864 hydrochloride

Cat. No. 3355

PNU 177864 hydrochloride C18H21F3N2O3S.HCl [250266-51-4]

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Chemical Name: N-[4-[2-(Propylamino)ethyl)phenyl]-4-(trifluoromethoxy)-benzenesulfonamide hydrochloride

Biological Activity

Highly selective dopamine D3 receptor antagonist. Induces phospholipidosis and exhibits antischizophrenic activity in vivo.

Technical Data

Soluble to 20 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rudmann et al (2004) Epididymal and systemic phospholipidosis in rats and dogs treated with dopamine D3 selective antagonist PNU-177864. Toxicol.Pathol. 32 326. PMID: 15204974.

Vonderfecht et al (2004) Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrence. Toxicol.Pathol. 32 318. PMID: 15204973.

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Citations are publications that use Tocris products.

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Keywords: PNU 177864 hydrochloride, supplier, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, PNU177864, hydrochloride, Tocris Bioscience, D3 Receptor Antagonist products

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