Cat. No. 0457
Chemical Name: 3-Chloro-10,11-dihydro-N,N-dimethyl
Biological ActivityPotent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a Ki of 0.05 nmol/l.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305. PMID: 9400006.
Ortiz and Artiga (1992) Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine. Br.J.Pharmacol. 105 941. PMID: 1387022.
McTavish and Benfield (1990) Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 39 136. PMID: 2178909.
Merck Index 12 2447.
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Keywords: Clomipramine hydrochloride, supplier, 5HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Tocris Bioscience, 5-HT Transporter Inhibitor products