Clomipramine hydrochloride

Cat. No. 0457

Clomipramine hydrochloride C19H23ClN2.HCl [17321-77-6]

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Chemical Name: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride

Biological Activity

Potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a Ki of 0.05 nmol/l.

Technical Data

M.Wt:
351.32
Formula:
C19H23ClN2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
17321-77-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305. PMID: 9400006.

Ortiz and Artiga (1992) Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine. Br.J.Pharmacol. 105 941. PMID: 1387022.

McTavish and Benfield (1990) Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 39 136. PMID: 2178909.

Merck Index 12 2447.

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Citations are publications that use Tocris products. Selected citations for Clomipramine hydrochloride include:

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. Eur J Neurosci 352 53. PMID: 25332454.

Duncan et al (2010) The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors. J Biomed Sci 31 1646. PMID: 20525077.

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Keywords: Clomipramine hydrochloride, supplier, 5HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Tocris Bioscience, 5-HT Transporter Inhibitor products

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