PSN 375963 hydrochloride

Cat. No. 3353

PSN 375963 hydrochloride C17H23N3O.HCl [388575-52-8]

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Chemical Name: 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine hydrochloride

Biological Activity

GPR119 receptor agonist (EC50 values are 8.4 and 7.9 μM at human and mouse receptors respectively). Displays similar potency to the endogenous ligand oleylethanolamide (OEA) (Cat. No. 1484).

Technical Data

M.Wt:
321.84
Formula:
C17H23N3O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
388575-52-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ning et al (2008) Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br.J.Pharmacol. 155 1056. PMID: 18724386.

Overton et al (2006) Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3 167. PMID: 16517404.

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Keywords: PSN 375963 hydrochloride, supplier, GPR119, receptors, agonists, PSN375963, hydrochloride, Tocris Bioscience, GPR119 Agonist products

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