Cat. No. 1118
Biological ActivityAn endogenous peptide derived from the same precursor as nociceptin, which is able to block nociceptin-induced allodynia and hyperalgesia and may play an opposing role in pain transmission. Shown to reverse nociceptin inhibition of glutamate release from rat brain slices; also modulates 5-HT transmission in the mouse neocortex via mechanisms separate from nociceptin/orphanin FQ.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fantin et al (2007) Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways. Br.J.Pharmacol. 152 549. PMID: 17618307.
Yamamoto et al (1999) Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test. Neurosci.Lett. 262 179. PMID: 10218885.
Nicol et al (1998) Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices. Eur.J.Pharmacol. 356 R1. PMID: 9774260.
Okuda-Ashitaka et al (1998) Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature 392 286. PMID: 9521323.
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Keywords: Nocistatin (bovine), supplier, blocker, nociceptin, receptors, ORL1, OP4, NOP, opioid, reverses, nociceptin, Tocris Bioscience, NOP Receptor Antagonist products
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