Cat. No. 1118
Biological ActivityAn endogenous peptide derived from the same precursor as nociceptin, which is able to block nociceptin-induced allodynia and hyperalgesia and may play an opposing role in pain transmission. Shown to reverse nociceptin inhibition of glutamate release from rat brain slices; also modulates 5-HT transmission in the mouse neocortex via mechanisms separate from nociceptin/orphanin FQ.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fantin et al (2007) Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways. Br.J.Pharmacol. 152 549. PMID: 17618307.
Yamamoto et al (1999) Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test. Neurosci.Lett. 262 179. PMID: 10218885.
Nicol et al (1998) Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices. Eur.J.Pharmacol. 356 R1. PMID: 9774260.
Okuda-Ashitaka et al (1998) Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature 392 286. PMID: 9521323.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Nocistatin (bovine) from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Nocistatin (bovine), supplier, blocker, nociceptin, receptors, ORL1, OP4, NOP, opioid, reverses, nociceptin, Tocris Bioscience, NOP Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599)BMS 986187
Potent δ-opioid receptor positive allosteric modulator
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.